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Multisystem inflammatory syndrome in children (MIS-C)

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Definition:
Multisystem inflammatory syndrome (MIS-C) ses hos barn och ungdomar med aktiv eller nyligen genomgådd SARS-CoV-2.
Förekomst:
Mycket ovanligt tillstånd, men rapporterade fall finns i Sverige. I USA 570 fall under perioden mars-juli 2020.
Symtom:
Ett spektrum av symtom inkluderande hög feber samt varierande grad av påverkan på ett eller flera organ. Två eller flera organsystem involverade, hög andel av chock, andningsbesvär och behov av intensivvård.
Kliniska fynd:
Feber, buksmärta, takypné, utslag, konjunktivit, tecken på hjärtskada, nedsatt allmänt tillstånd.
Diagnostik:
Feber, påvisande av multiorgan-sjukdom, förhöjda inflammationsmarkörer och tecken på ökad koagulering.
Behandling:
Intensivvårdsbehandling, eventuellt ventilationsstöd. IVIG och acetylsalicylsyra till alla som också uppfyller Kawasaki-kriterierna.
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