Missfall i andra trimestern
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Sakkunnig:NuvarandeBritt Friberg- Missfall i andra trimestern är relativt sällsynt.
- Detta beror på förhållanden hos fostret eller modern. Kromosomfel antas vara förklaringen i 25 %.
- Ofta relaterat till bristande moderkaksfunktion och tillväxthämning. 3
- Maternella faktorer är anatomiska förhållanden, immunologiska faktorer, infektion och trombofili.
- Det är svårt att identifiera den specifika orsaken i det enskilda fallet.
- Sparsamt med dokumentation på att specifika insatser hjälper.
- Michels TC, Tiu AY. Second trimester pregnancy loss. Am Fam Physician 2007; 76: 1341-6. PubMed
- Flint S, Gibb DM. Recurrent second trimester miscarriage. Curr Opin Obstet Gynecol 1996; 8: 449-53. PubMed
- Flenady V, Koopmans L, Middleton P, et al. Major risk factors for stillbirth in high income countries: a systematic review and meta-analysis. Lancet 2011; 377: 1331-40. PubMed
- Wang X, Chen C, Wang L, Chen D, Guang W, French J. Conception, early pregnancy loss, and time to clinical pregnancy: a population-based prospective study. Fertil Steril 2003; 79: 577-84. PubMed
- Wilcox AJ, Weinberg CR, O'Connor JF, Baird DD, Schlatterer JP, Canfield RE, et al. Incidence of early loss of pregnancy. N Engl J Med 1988; 319: 189-94. New England Journal of Medicine
- Goldenberg L, Kirby R, Culhane JF. Stillbirth: a review. J Matern Fetal Neonatal Med 2004; 16: 79-94. PubMed
- Petitti DB. The epidemiology of fetal death. Clin Obstet Gynecol 1987; 30: 253-8. PubMed
- Ahlenius I, Floberg J, Thomassen P. Sixty-six cases of intrauterine fetal death. A prospective study with an extensive test protocol. Acta Obstet Gynecol Scand 1995; 74: 109-17. PubMed
- Fretts RC, Usher RH. Causes of fetal death in women of advanced maternal age. Obstet Gynecol 1997; 89: 40-5. PubMed
- Reddy UM, Laughon SK, Sun L, et al. Prepregnancy risk factors for antepartum stillbirth in the United States. Obstet Gynecol 2010; 116: 1119-26. PubMed
- Warburton D, Kline J, Stein Z, Strobino B. Cytogenetic abnormalities in spontaneous abortions of recognized conceptions. In: Porter IH, Hatcher NH, Willey AM, eds. Perinatal Genetics: Diagnosis and Treatment. Orlando, Fla.: Academic Press, 1986: 23-40.
- Simpson JL. Fetal wastage. In: Gabbe SG, Niebyl JR, Simpson JL. Obstetrics: Normal and Problem Pregnancies. 3rd ed. New York, N.Y.: Churchill Livingstone, 1996: 717-42.
- The American Fertility Society classifications of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, müllerian anomalies and intrauterine adhesions. Fertil Steril 1988; 49: 944-55. PubMed
- Stampe Sorensen S. Estimated prevalence of müllerian anomalies. Acta Obstet Gynecol Scand 1988; 67: 441-5. PubMed
- Lin PC, Bhatnagar KP, Nettleton GS, Nakajima ST. Female genital anomalies affecting reproduction. Fertil Steril 2002; 78: 899-915. PubMed
- Patton PE, Novy MJ, Lee DM, Hickok LR. The diagnosis and reproductive outcome after surgical treatment of the complete septate uterus, duplicated cervix and vaginal septum. Am J Obstet Gynecol 2004; 190: 1669-75. PubMed
- Berghella V. Grand rounds: the short and funneled cervix: what do I do now? Contemp Ob/Gyn 2004; 49: 26-34.
- Rice JP, Kay HH, Mahony BS. The clinical significance of uterine leiomyomas in pregnancy. Am J Obstet Gynecol 1989; 160(5 pt 1): 1212-6.
- Belej-Rak T, Okun N, Windrim R, Ross S, Hannah ME. Effectiveness of cervical cerclage for a sonographically shortened cervix: a systematic review and meta-analysis. Am J Obstet Gynecol 2003; 189: 1679-87. PubMed
- American College of Obstetricians and Gynecologists. ACOG practice bulletin. Cervical insufficiency. Obstet Gynecol 2003; 102(5 pt 1): 1091-9.
- Drakeley AJ, Roberts D, Alfirevic Z. Cervical cerclage for prevention of preterm delivery: meta-analysis of randomized trials Published correction appears in Obstet Gynecol 2004;103:201. Obstet Gynecol 2003; 102: 621-7. PubMed
- Rey E, Kahn SR, David M, Shrier I. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 2003; 361: 901-8. PubMed
- Wilson WA, Gharavi AE, Koike T, Lockshin MD, Branch DW, Piette JC, et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum 1999; 42: 1309-11. PubMed
- Empson M, Lassere M, Craig J, Scott J. Prevention of recurrent miscarriage for women with antiphospholipid antibody syndrome or lupus anticoagulant. Cochrane Database Syst Rev, issue 2, 2005. The Cochrane Library
- Walker MC, Ferguson SE, Allen VM. Heparin for pregnant women with acquired or inherited thrombophilias. Cochrane Database Syst Rev, issue 2, 2003. The Cochrane Library
- Heller DS, Moorehouse-Moore C, Skurnick J, Baergen RN. Second- trimester pregnancy loss at an urban hospital. Infect Dis Obstet Gynecol 2003; 11: 117-22. PubMed
- Hay PE. Bacterial vaginosis and miscarriage. Curr Opin Infect Dis 2004; 17: 41-4. PubMed
- McDonald HM, Brocklehurst P, Gordon A. Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev, issue 1, 2007. The Cochrane Library
- Incerpi MH, Miller DA, Samadi R, Settlage RH, Goodwin TM. Stillbirth evaluation: what tests are needed? Am J Obstet Gynecol 1998; 178: 1121-5. PubMed
- Stierman ED. Emotional aspects of perinatal death. Clin Obstet Gynecol 1987; 30: 352-61. PubMed
- Flenady V, Wilson T. Support for mothers, fathers and families after perinatal death. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD000452 Cochrane (DOI)
- NuvarandeBritt Friberg, docent och överläkare, Reproduktionsmedicinskt Centrum, Malmö, och Kvinnokliniken, Skånes universitetssjukhus
- Tidigare:Terje Johannessen, professor i allmänmedicin, Institutt for samfunnsmedisinske fag, Norges teknisk-naturvitenskapelige universitet, TrondheimPer Bergsjø, professor emeritus, dr. med., Universitetet i Bergen. Specialist i kvinnosjukdomar och förlossningshjälp, forskare vid Nasjonalt folkehelseinstitutt, Oslo
Tidigare sakkunniga
- Terje Johannessen, professor i allmänmedicin, Institutt for samfunnsmedisinske fag, Norges teknisk-naturvitenskapelige universitet, Trondheim
- Per Bergsjø, professor emeritus, dr. med., Universitetet i Bergen. Specialist i kvinnosjukdomar och förlossningshjälp, forskare vid Nasjonalt folkehelseinstitutt, Oslo