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Återkommande spontanaborter (habituell abort)

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  1. Rai R, Regan L. Recurrent miscarriage. Lancet 2006; 368: 601-11. PubMed  
  2. Wilcox AJ, Weinberg CR, O'Connor JF, et al. Incidence of early loss of pregnancy. N Engl J Med 1988; 319: 189-94. New England Journal of Medicine  
  3. Stirrat GM. Recurrent miscarriage. Lancet 1990; 336: 673-5. PubMed  
  4. Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J and Melbye M. Maternal age and fetal loss: population based register linkage study. BMJ 2000; 320: 1708-12. British Medical Journal  
  5. Fritz B, Hallermann C, Olert J, et al. Cytogenetic analyses of culture failures by comparative genomic hybridisation (CGH) - Re-evaluation of chromosome aberration rates in early spontaneous abortions. Eur J Hum Genet 2001; 9: 539-47. PubMed  
  6. Phillipp T, Phillipp K, Reiner A, Beer F and Kalousek DK. Embryoscopic and cytogenetic analysis of 233 missed abortions: factors involved in the pathogenesis of developmental defects of early failed pregnancies. Hum Reprod 2003; 18: 1724-32. PubMed  
  7. Hart R, Khalaf Y, Yeong CT, Seed P, Taylor A and Braude P. A prospective controlled study of the effect of intramural uterine fibroids on the outcome of assisted conception. Hum Reprod 2001; 16: 2411-7. PubMed  
  8. Drakeley AJ, Quenby S and Farquharson RG. Mid-trimester loss - appraisal of a screening approach. Hum Reprod 1998; 13: 1975-80. PubMed  
  9. Kovalevsky G, Gracia CR, Berlin JA, Sammel MD and Barnhart KT. Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysis. Arch Intern Med 2004; 164: 558-63. PubMed  
  10. Rey E, Kahn SR, David M and Shrier I. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 2003; 361: 901-8. PubMed  
  11. Christiansen OB, Steffensen R, Nielsen HS, Varming K. Multifactorial etiology of recurrent miscarriage and its scientific and clinical implications.. Gynecol Obstet Invest 2008; 66: 257-67. PubMed  
  12. Regan L. Recurrent miscarriage. BMJ 1991; 302: 543-4. British Medical Journal  
  13. Craig LB, Ke RW and Kutteh WH. Increased prevalence of insulin resistance in women with a history of recurrent pregnancy loss. Fertil Steril 2002; 78: 487-90. PubMed  
  14. Empson M, Lassere M, Craig JC and Scott JR. Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials. Obstet Gynecol 2002; 99: 135-44. PubMed  
  15. Kesmodel U, Wisborg K, Olsen SF, et al. Moderate alcohol intake in pregnancy and the risk of spontaneous abortion. Alcohol Alcohol 2002; 37: 435-44. PubMed  
  16. Rasch V. Cigarette, alcohol and caffeine consumption: Risk factors for spontaneous abortion. Acta Obstet Gynecol Scand 2003; 82: 182-8. PubMed  
  17. Sullivan AE, Silver RM, LaCoursiere DY, Porter TF and Branch DW. Recurrent fetal aneuploidy and recurrent miscarriage. Obstet Gynecol 2004; 104: 784-8. PubMed  
  18. Lindbohm ML, Sallmen M and Taskinen H. Effects of exposure to environmental tobacco smoke on reproductive health. Scand J Work Environ Health 2002; 28 (suppl 2): 84-96.
  19. Lashen H, Fear K and Sturdee DW. Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study. Hum Reprod 2004; 19: 1644-6. PubMed  
  20. Oates-Whitehead RM, Haas DM and Carrier JA. Progestogen for preventing miscarriage. Cochrane Database Syst Rev, issue 4, 2003. The Cochrane Library  
  21. Daya S. Efficacy of progesterone support for pregnancy in women with recurrent miscarriage. A meta-analysis of controlled trials. Br J Obstet Gynaecol 1989; 96: 275-80. PubMed  
  22. Kaandorp SP, et al. Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med 2010; 362: 1586. New England Journal of Medicine  
  23. Lockwood CJ, Schur PH. Management of pregnant women with antiphospholipid antibodies or the antiphospholipid syndrome. UpToDate, last updated Nov 19, 2008. UpToDate  
  24. Farquharson RG, Quenby S, Greaves M. Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment. Obstet Gynecol 2002; 100: 408. PubMed  
  25. Lockwood CJ, Bauer KA. Inherited thrombophilias in pregnancy. UpToDate, last updated Jan 30, 2009. UpToDate  
  26. Gris JC, Mercier E, Quere I, et al. Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood 2004; 103: 3695. Blood  
  27. Nelson SM and Greer IA. The potential role of heparin in assisted conception. Human Reprod 2008; 14: 623-45. PubMed  
  28. Badawy AM, Khiary M, Sherif LS, Hassan M, Ragab A, Abdelall I. Low-molecular weight heparin in patients with recurrent early miscarriages of unknown aetiology.. J Obstet Gynaecol 2008; 28: 280-4. PubMed  
  29. Stephenson MD, Awartani KA and Robinson WP. Cytogenetic analysis of miscarriages from couples with recurrent miscarriage: a case-control study. Hum Reprod 2002; 17: 446-51. PubMed  
  30. Greenwold N and Jauniaux E. Collection of villous tissue under ultrasound guidance to improve the cytogenetic study of early pregnancy failure. Hum Reprod 2002; 17: 452-6. PubMed  
  31. Drakeley AJ, Roberts D and Alfirevic Z. Cervical stitch (cerclage) for preventing pregnancy loss in women. Cochrane Database Syst Rev, issue 1, 2003. The Cochrane Library  
  32. Hay PE, Lamont RF, Taylor-Robinson D, Morgan DJ, Ison C and Pearson J. Abnormal bacterial colonisation of the genital tract and subsequent preterm delivery and late miscarriage. BMJ 1994; 308: 295-8. British Medical Journal  
  33. Ugwumade A, Manyonda I, Reid F and Hay P. Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis. Lancet 2003; 361: 983-98. PubMed  
  34. Brocklehurst P, Hanna M and McDonald H. Interventions for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev, issue 2, 2000. The Cochrane Library  
  35. Kutteh WH. Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone. Am J Obstet Gynecol 1996; 174: 1584-9. PubMed  
  36. Rai R, Cohen H, Dave M and Regan L. Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). BMJ 1997; 314: 253-7. British Medical Journal  
  37. Jivraj S, Anstie B, Cheong YC, Fairlie FM, Laird S and Li TC. Obstetric and neonatal outcome in women with a history of recurrent miscarriage: a cohort study. Hum Reprod 2001; 16: 102-6. PubMed  
  • Britt Friberg, docent och överläkare, Reproduktionsmedicinskt Centrum, Malmö, och Kvinnokliniken, Skånes universitetssjukhus

Tidigare sakkunniga

  • Terje Johannessen, professor i allmänmedicin, Institutt for samfunnsmedisinske fag, Norges teknisk-naturvitenskapelige universitet, Trondheim