Fruktosmalabsorption
Senast uppdaterad: Senast reviderad:
Sakkunnig:Remy Waardenburg
Definition:
Malabsorption av fruktos är vanligt både bland patienter med ospecifika magbesvär och bland friska människor. Det är osäkert vilken klinisk betydelse tillståndet har.
Förekomst:
Sannolikt ett vanligt tillstånd.
Symtom:
Symtom på malabsorption av kolhydrater är gasbesvär, magkramper, magsmärtor och diarré, och ibland huvudvärk och stämningspåverkan.
Kliniska fynd:
Inga specifika.
Diagnostik:
Diagnosen kan misstänkas vid påtaglig förbättring om fruktosen utesluts från kosten eller utesluts.
Behandling:
Består av koständringar med undvikande av fruktosrik kost.
- Dolan LC, Potter SM, Burdock GA. Evidence-based review on the effect of normal dietary consumption of fructose on blood lipids and body weight of overweight and obese individuals. Crit Rev Food Sci Nutr 2010;50: 889-918. PubMed
- Born P. Carbohydrate malabsorption in patients with non-specific abdominal complaints. World J Gastroenterol 2007; 13: 5687-91. PubMed
- Gibson PR, Newnham E, Barrett JS, Shepherd SJ, Muir JG. Review article: fructose malabsorption and the bigger picture. Aliment Pharmacol Ther 2007; 25: 349-63. PubMed
- Kyaw MH, Mayberry JF. Fructose malabsorption: True condition or a variance from normality. J Clin Gastroenterol 2011; 45: 16-21. PubMed
- Montalto M, Gallo A, Ojetti V, et al. Fructose, trehalose and sorbitol malabsorption. Eur Rev Med Pharmacol Sci 2013; 17: Suppl 2:26-9. pmid:24443064 PubMed
- Mason JB, Milovic V, Seres D, et al. Overview of the treatment of malabsorption. UpToDate 2018. www.uptodate.com
- Rao SS, Attaluri A, Anderson L, et al. Ability of the normal human small intestine to absorb fructose: evaluation by breath testing. Clin Gastroenterol Hepatol 2007; 5(8): 959-63. pmid:17625977 PubMed
- Drozdowski LA, Thomson AB. Intestinal sugar transport. World J Gastroenterol 2006; 12: 1657-1670. PubMed
- Park YK, Yetley EA. Intakes and food sources of fructose in the United States. Am J Clin Nutr 1993; 58 (Suppl.): 737-47.
- Wilder-Smith CH, Li X, Ho SS, et al. Fructose transporters GLUT5 and GLUT2 expression in adult patients with fructose intolerance. United European Gastroenterol J 2014; 2(1): 14-21. pmid:24918004 PubMed
- Andersson DE, Nygren A. Four cases of long-standing diarrhoea and colic pains cured by fructose-free diet: a pathogenetic discussion. Acta Med Scand 1978; 203: 87-92. PubMed
- Shepherd SJ, Parker FC, Muir JG, Gibson PR. Dietary triggers of abdominal symptoms in patients with irritable bowel syndrome: randomized placebo-controlled evidence. Clin Gastroenterol Hepatol 2008; 6:765. PubMed
- Born P, Zech J, Lehn H, Classen M, Lorenz R. Colonic bacterial activity determines the symptoms in people with fructosemalabsorption. Hepatogastroenterology 1995; 42: 778-85. PubMed
- Popkin BM, Nielsen SM. The sweetening of the world's diet. Obesity Res 2003; 11: 1325-32. PMID: 14627752 PubMed
- van Nieuwenhoven MA, Brouns F, Kovacs EMR. The effect of two sports drinks and water on GI complaints and performance during an 18-km run. Int J Sports Med 2005; 26: 281–5.
- Ledochowski M, Widner B, Bair H, Probst T, Fuchs D. Fructose- and sorbitol-reduced diet improves mood and gastrointestinal disturbances in fructose malabsorbers. Scand J Gastroenterol 2000; 35: 1048-52. PubMed
- Fedewa A, Rao SS. Dietary fructose intolerance, fructan intolerance and FODMAPs. Curr Gastroenterol Rep 2014; 16(1): 370. pmid:24357350 PubMed
- Fernandez-Banares F, Rosinach M, Esteve M, Forne M, Espinos JC, Maria Viver J. Sugar malabsorption in functional abdominal bloating: a pilot study on the long-term effect of dietary treatment. Clin Nutr 2006; 25: 824-31. PubMed
- Putkonen L, Yao CK, Gibson PR, Fructose malabsorption syndrome. Curr Opin Clin Nutr Metab Care 2013;16: 473-7. PubMed
- Remy Waardenburg, specialist i allmänmedicin, medicinsk redaktör Medibas
Tidigare sakkunniga
- Henrik Forssell, docent och överläkare, kirurgkliniken, Blekingesjukhuset, Karlskrona