Divertikelsjukdom
Senast uppdaterad: Senast reviderad:
Sakkunnig:Anna Nager
Definition:
Divertikulos är ett tillstånd med divertiklar i form av kolonmukosa som hernierar genom muscularis, främst i sigmoideum men också i kolon descendens och ibland i högerkolon. Divertikelsjukdom betecknar divertikulos med symtom.
Förekomst:
Prevalensen divertikulos var 27 % för alla åldrar och 60–80 % >60 års ålder i en stor nederländsk undersökning. Divertikulit utvecklas hos cirka 1–4 % av personer med divertiklar i kolon.
Symtom:
Symtom kan vara ändrade avföringsvanor, vänstersidiga koliksmärtor som lindras vid defekation och gasbildning. Divertikulos är asymtomatiskt hos 80–90 %.
Kliniska fynd:
Oftast inga kliniska fynd. Vid divertikulit föreligger feber och palpationsömhet företrädesvis i nedre vänsterkvadranten. Divertiklar kan ibland leda till tarmblödning.
Diagnostik:
Vid akut divertikulit ses typiska röntgenfynd på DT buk i kombination med stegrade inflammationsparametrar. Vid genomgången förstagångsdivertikulit bör patienten genomgå koloskopi eller DT kolon efter 4–6 veckor för att utesluta koloncancer.
Behandling:
Divertikelsjukdom kräver oftast ingen annan behandling än information. Vid okomplicerad divertikulit rekommenderas tarmvila (alternativt skonkost/flytande kost om patienten har återgått till hemmet). Vid komplicerad divertikulit ges även antibiotika. I vissa fall krävs kirurgi.
- Salzman H, Lillie D. Diverticular disease: Diagnosis and treatment. Am Fam Physician 2005; 72: 1229-34. PubMed
- Stollman N, Raskin JB. Diverticular disease of the colon. Lancet 2004; 363: 631-9. PubMed
- Young-Fadok TM, Roberts PL, Spencer MP, Wolff BG. Colonic diverticular disease. Curr Probl Surg 2000; 37: 457-514. PubMed
- Janes SEJ, Meagher A, Frizelle FA. Management of diverticulitis. BMJ 2006; 332: 271-5. PubMed
- Jacobs DO. Diverticulitis. N Engl J Med 2007; 357: 2057-66. PubMed
- Loffeld RJ, Van Der Putten AB. Diverticular disease of the colon and concomitant abnormalities in patients undergoing endoscopic evaluation of the large bowel. Colorectal Dis 2002; 4: 189-92. PubMed
- Peery AF.Recent Advances in Diverticular Disease. Curr Gastroenterol Rep. 2016 Jul;18(7):37. PMID: 27241190. PubMed
- Mäkelä J, Kiviniemi H, Laitinen S. Prevalence of perforated sigmoid diverticulitis is increasing. Dis Colon Rectum 2002; 45: 955-61. PubMed
- Kang JY, Hoare J, Tinto A, Subramanian S, Ellis C, Majeed A, Melville D, Maxwell JD. Diverticular disease of the colon--on the rise: a study of hospital admissions in England between 1989/1990 and 1999/2000. Aliment Pharmacol Ther. 2003 May 1;17(9):1189-95. PubMed PMID: 12752356 PubMed
- Simpson J, Scholefield JH, Spiller RC. Pathogenesis of colonic diverticula. Br J Surg 2002; 89: 546-54. PubMed
- Granlund J, Svensson T, Olén O, Hjern F, Pedersen NL, Magnusson PK, Schmidt PT. The genetic influence on diverticular disease--a twin study. Aliment Pharmacol Ther. 2012 May;35(9):1103-7. doi: 10.1111/j.1365-2036.2012.05069.x. Epub 2012 Mar 20. PubMed PMID: 22432696 PubMed
- Bode MK, Karttunen TJ, Makela J, Risteli L, Risteli J. Type I and III collagens in human colon cancer and diverticulosis. Scand J Gastroenterol 2000; 35: 747-52. PubMed
- Camilleri M, Sandler RS, Peery AF. Etiopathogenetic Mechanisms in Diverticular Disease of the Colon. Cell Mol Gastroenterol Hepatol. 2020;9(1):15-32. doi: 10.1016/j.jcmgh.2019.07.007. Epub 2019 Jul 25. PMID: 31351939 PubMed
- Meyers MA, Alonso DR, Gray GF, Baer JW. Pathogenesis of bleeding colonic diverticulosis. Gastroenterology. 1976 Oct;71(4):577-83. PMID: 1085269 PubMed
- Wong SK, Ho YH, Leong AP, Seow-Choen F. Clinical behavior of complicated right-sided and left-sided diverticulosis. Dis Colon Rectum 1997; 40: 344-8. PubMed
- Wilkins T, Baird C, Pearson AN, Schade RR. Diverticular bleeding. Am Fam Physician. 2009 Nov 1;80(9):977-83. PMID: 19873964 PubMed
- Strate LL, Orav EJ, Syngal S. Early predictors of severity in acute lower intestinal tract bleeding. Arch Intern Med 2003; 163: 838-43. PubMed
- Shah SD, Cifu AS. Management of Acute Diverticulitis. JAMA. 2017 Jul 18;318(3):291-292. doi: 10.1001/jama.2017.6373. PMID: 28719679 PubMed
- Halligan S, Saunders B. Imaging diverticular disease. Best Pract Res Clin Gastroenterol 2002; 16: 595-610. PubMed
- van Dijk ST, Daniels L, de Korte N, et al. Quality of Life and Persistent Symptoms After Uncomplicated Acute Diverticulitis. Dis Colon Rectum. 2019 May;62(5):608-614. pmid:30807455 PubMed
- Reinus JF, Brandt LJ. Vascular ectasias and diverticulosis. Common causes of lower intestinal bleeding. Gastroenterol Clin North Am 1994; 23: 1-20. PubMed
- Fine KD, Nelson AC, Ellington RT, Mossburg A. Comparison of the color of fecal blood with the anatomical location of gastrointestinal bleeding lesions: potential misdiagnosis using only flexible sigmoidoscopy for bright red blood per rectum. Am J Gastroenterol 1999; 94: 3202-10. PubMed
- Altman D, Forsgren C, Hjern F, Lundholm C, Cnattingius S, Johansson AL. Influence of hysterectomy on fistula formation in women with diverticulitis. Br J Surg. 2010 Feb;97(2):251-7. doi: 10.1002/bjs.6855. PubMed PMID: 20035535 PubMed
- Hjern F, Goldberg SM, Johansson C, Parker SC, Mellgren A. Management of diverticular fistulae to the female genital tract. Colorectal Dis. 2007 Jun;9(5):438-42. PubMed PMID: 17504341 PubMed
- Thaha MA, Carrington E. Diverticular disease. BMJ BestPractice, last updated 15 Oct 2019. bestpractice.bmj.com
- Thorson CM, PazRuiz PS et al. The perforated duodenal diverticulum. Arch Surg 2012; 47 (1): 81-8. pmid: 22250120 PubMed
- Divertikulit. Nationellt kliniskt kunskapsstöd, NKK (hämtad 2021-12-20) nationelltklinisktkunskapsstod.se
- Janes SEJ, Meagher A, Frizelle FA. Elective surgery after acute diverticulitis. Br J Surg 2005; 92: 133-42. PubMed
- de Korte N, Unlü C et al. Use of antibiotics in uncomplicated diverticulitis.. Br J Surg 2011; 98(6): 761-767. PubMed
- Chabok A, Påhlman L et al. Randomized clinical trial of antibiotics in acute uncomplicated diverticulitis. Br J Surg 2012; 99(4): 532-539. PubMed
- Ünlü C, Daniels L et al. A systematic review of high-fibre dietary therapy in diverticular disease. Int J Colorectal Dis 2012; 27(4): 419-27. pmid:21922199 PubMed
- Hart AR, Kennedy HJ, Stebbings WS, Day NE. How frequently do large bowel diverticula perforate? An incidence and cross-sectional study. Eur J Gastroenterol Hepatol 2000; 12: 661-5. PubMed
- Hjern F, Mahmood MW, Abraham-Nordling M, Wolk A, Håkansson N. Cohort study of corticosteroid use and risk of hospital admission for diverticular disease. Br J Surg. 2015 Jan;102(1):119-24. doi: 10.1002/bjs.9686. Epub 2014 Nov 12. PubMed PMID: 25389076 PubMed
- van Dijk ST, Daniels L, Unlu C, et al. Long-Term Effects of Omitting Antibiotics in Uncomplicated Acute Diverticulitis. Am J Gastroenterol 2018. pmid:29700480 www.ncbi.nlm.nih.gov
- Reisman Y, Ziv Y, Kravrovitc D, Negri M, Wolloch Y, Halevy A. Diverticulitis: the effect of age and location on the course of disease. Int J Colorectal Dis 1999; 14: 250-4. PubMed
- Angenete E, Thornell A, Burcharth J et al. Laparoscopic Lavage Is Feasible and Safe for the Treatment of Perforated Diverticulitis With Purulent Peritonitis: The First Results From the Randomized Controlled Trial DILALA. Ann Surg. 2016 Jan;263(1):117-22. PMID: 25489672 PubMed
- Angenete E, Bock D, Rosenberg J, Haglind E. Laparoscopic lavage is superior to colon resection for perforated purulent diverticulitis-a meta-analysis. Int J Colorectal Dis. 2017 Feb;32(2):163-169. doi: 10.1007/s00384-016-2636-0. Epub 2016 Aug 27. PMID: 27567926 PubMed
- Bissolati M, Orsenigo E, Staudacher C, et al. Role of minimally invasive surgery in the treatment of diverticular disease: an evidence-based analysis. Updates Surg. 2015 Dec;67(4):353-65. pmid: 26449963 PubMed
- Wong WD, Wexner SD, Lowry A, et al. Practice parameters for the treatment of sigmoid diverticulitis: supporting documentation. Dis Colon Rectum 2000; 43: 290-97. PubMed
- Schultz JK, Yaqub S, Wallon C, et al. Laparoscopic lavage vs primary resection for acute perforated diverticulitis. The SCANDIV randomized clinical trial. JAMA 2015; 314: 1364-75. doi:10.1001/jama.2015.12076 DOI
- Zuckerman GR, Prakash C. Acute lower intestinal bleeding: part II--etiology, therapy, and outcomes. Gastrointest Endosc 1999; 49: 228-38. PubMed
- Davila RE, Rajan E, Adler DG, et al., for the Standards of Practice Committee. ASGE Guideline: the role of endoscopy in the patient with lower-GI bleeding. Gastrointest Endosc 2005; 62: 656-60. PubMed
- Chen CY, Wu CC, Jao SW, Pai L, Hsiao CW. Colonic diverticular bleeding with comorbid diseases may need elective colectomy. J Gastrointest Surg 2009; 13: 516-20 PubMed
- Haglund U, Hellberg R, Johnsen C, Hulten L. Complicated diverticular disease of the sigmoid colon. An analysis of short and long term outcome in 392 patients. Ann Chir Gynaecol 1979; 68: 41-6. PubMed
- Goh H, Bourne R. Non-steroidal anti-inflammatory drugs and perforated diverticular disease: a case-control study. Ann R Coll Surg Engl 2002; 84: 93-6. PubMed
- Salem TA, Molloy RG, O'Dwyer PJ. Prospective, five-year follow-up study of patients with symptomatic uncomplicated diverticular disease. Dis Colon Rectum 2007; 50: 1460-4. PubMed
- Munson KD, Hensien MA, Jacob LN, Robinson AM, Liston WA. Diverticulitis. A comprehensive follow-up. Dis Colon Rectum 1996; 39: 318-22. PubMed
- Sarin S, Boulos PB. Long-term outcome of patients presenting with acute complications of diverticular disease. Ann R Coll Surg Engl 1994; 76: 117-20. PubMed
- Simpson J, Spiller R. Colonic diverticular disease. Clinical Evidence 2001; 6: 336-43. PubMed
- Chabok A, Thorisson A, Nikberg M, Schultz JK, Sallinen V. Changing Paradigms in the Management of Acute Uncomplicated Diverticulitis. Scand J Surg. 2021 Jun;110(2):180-186. doi: 10.1177/14574969211011032. Epub 2021 May 3. PMID: 33934672 PubMed
- Divertikulit. Akut kirurgi, behandlingshandbok 2022. Region Stockholm kunskapsstodforvardgivare.se
- Standardiserat vårdförlopp, tjock- och ändtarmscancer, kortversion för primärvården (hämtad 2022-04-05) cancercentrum.se
- Anna Nager, docent och specialist i allmänmedicin, Karolinska institutet