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Metabola syndromet

Senast uppdaterad: Senast reviderad:

En samling riskfaktorer som inkluderar bukfetma, insulinresistens, dyslipidemi och hypertoni.
Vanligt tillstånd. Förekomsten varierar med definition och population. 
I tidig fas få symtom utöver bukfetma.
Kliniska fynd:
Hypertoni och bukfetma.
Högt BMI, förhöjda triglycerider, lågt HDL-kolesterol, förhöjt fasteglukos/HbA1c eller nedsatt glukostolerans.
Förändring i kosthållning och ökad fysisk aktivitet för att uppnå viktminskning och förbättring av övriga riskfaktorer. Rökstopp.
  1. Deen D. Metabolic syndrome: Time for action. Am Fam Physician 2004; 69: 2875-82. PubMed  
  2. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005; 365: 1415-28. PubMed  
  3. Vega GL. Obesity, the metabolic syndrome, and cardiovascular disease. Am Heart J 2001; 142: 1108-16. PubMed  
  4. Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C, for The American Heart Association/ National Heart, Lung, and Blood Institute. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 2004; 109:433-8. Circulation  
  5. Ford ES, Giles WH. A comparison of the prevalence of the metabolic syndrome using two proposed definitions. Diabetes Care 2003; 26: 575-81. PubMed  
  6. Eckel RH, Krauss RM. American Heart Association call to action: obesity as a major risk factor for coronary heart disease. AHA Nutrition Committee. Circulation 1998; 97: 2099-100. Circulation  
  7. Gennuso KP, Gangnon RE, Thraen-Borowski KM, Colbert LH. Dose-response relationships between sedentary behaviour and the metabolic syndrome and its components. Diabetologia 2015; 58:485. PubMed  
  8. Lopez-Candales A. Metabolic syndrome X: a comprehensive review of the pathophysiology and recommended therapy. J Med 2001; 32: 283-300. PubMed  
  9. Bjorntorp P. Heart and soul: stress and the metabolic syndrome. Scand Cardiovasc J 2001; 35: 172-7. PubMed  
  10. Samson SL, Garber AJ. Metabolic syndrome. Endocrinol Metab Clin North Am. 2014 Mar;43(1):1-23. PMID: 24582089 PubMed  
  11. Hark L, Deen D Jr. Taking a nutrition history: a practical approach for family physicians. Am Fam Physician 1999; 59: 1521-8,1531-2. American Family Physician  
  12. National Institutes of Health: Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Executive Summary. Bethesda, Md.: National Institutes of Health, National Heart Lung and Blood Institute, 2001 (NIH publication no. 01-3670). Accessed online March 18, 2004, at: http://www.nhlbi.nih.gov/guidelines/cholesterol/index.htm.
  13. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al., for the National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report Published correction appears in JAMA 2003;290:197. JAMA 2003; 289: 2560-72. Journal of the American Medical Association  
  14. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al., for the Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393-403. New England Journal of Medicine  
  15. Gregg EW, Cauley JA, Stone K, Thompson TJ, Bauer DC, Cummings SR, et al., for the Study of Osteoporotic Fractures Research Group. Relationship of changes in physical activity and mortality among older women. JAMA 2003; 289: 2379-86. Journal of the American Medical Association  
  16. Duncan GE, Perri MG, Theriaque DW, Hutson AD, Eckel RH, Stacpoole PW. Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. Diabetes Care 2003; 26: 557-62. PubMed  
  17. Goodpaster BH, He J, Watkins S, Kelley DE. Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab 2001; 86: 5755-61. PubMed  
  18. Keller C, Trevino RP. Effects of two frequencies of walking on cardiovascular risk factor reduction in Mexican American women. Res Nurs Health 2001; 24: 390-401. PubMed  
  19. McInnis KJ, Franklin BA, Rippe JM. Counseling for physical activity in overweight and obese patients. Am Fam Physician 2003; 67: 1249-56. American Family Physician  
  20. Slentz CA, Duscha BD, Johnson JL, Ketchum K, Aiken LB, Samsa GP, et al. Effects of the amount of exercise on body weight, body composition, and measures of central obesity: STRRIDE-a randomized controlled study. Arch Intern Med 2004; 164: 31-9. PubMed  
  21. Ross R, Dagnone D, Jones PJ, Smith H, Paddags A, Hudson R, et al. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Ann Intern Med 2000; 133: 92-103. Annals of Internal Medicine  
  22. Szapary PO, Hark LA, Burke FM. The metabolic syndrome: a new focus for lifestyle modification. Patient Care 2002; 36: 75-88. PubMed  
  23. Vollmer WM, Sacks FM, Ard J, Appel LJ, Bray GA, Simons-Morton DG, et al., for the DASH-Sodium Trial Collaborative Research Group. Effects of diet and sodium intake on blood pressure: subgroup analysis of the DASH-sodium trial. Ann Intern Med 2001; 135: 1019-28. Annals of Internal Medicine  
  24. Adler AJ, Taylor F, Martin N, Gottlieb S, Taylor RS, Ebrahim S. Reduced dietary salt for the prevention of cardiovascular disease. Cochrane Database of Systematic Reviews 2014, Issue 12. Art. No.: CD009217. DOI: 10.1002/14651858.CD009217.pub3 DOI  
  25. Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 2003; 348: 2599-608. New England Journal of Medicine  
  26. Goude D, Fagerberg B, Hulthe J, for the AIR study group. Alcohol consumption, the metabolic syndrome and insulin resistance in 58-year-old clinically healthy men (AIR study). Clin Sci (London) 2002; 102: 345-52. PubMed  
  27. Ginsberg HN. Treatment for patients with the metabolic syndrome. Am J Cardiol 2003; 91(7A): 29E-39E.
  28. Gaede P, Vedel P, Larsen N, Jensen GV, Parving HH, Pedersen O. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med 2003; 348: 383-93. New England Journal of Medicine  
  • Ulla-Britt Ericsson, docent och specialist invärtesmedicin och endokrinologi, Malmö
  • Anna Nager, med dr och specialist i allmänmedicin, Karolinska institutet