Vulvovaginal lichen planus
Senast uppdaterad: Senast reviderad:
Sakkunnig:Barbro Larson
Definition:
Ett inflammatoriskt, autoimmunt tillstånd i keratiniserad hud och slemhinnor.
Förekomst:
Ovanligt tillstånd där incidensen är högst i åldersgruppen 30–60 år.
Symtom:
Klåda, brännande sveda, smärta, dyspareuni och postkoital blödning.
Kliniska fynd:
Erosiv, papuloskvamös eller hypertrofisk lichen planus.
Diagnostik:
Eventuellt biopsi.
Behandling:
Lokala kortisonmedel och lokalbedövande medel. Om lokalbehandling inte hjälper kan peroral kortikosteroid ges. I vissa fall används de immunhämmande preparaten takrolimus eller pimekrolimus.
- O'Conell TX, Nathan LS, Satmary WA, Goldstein AT. Non-neoplastic epithelial disorders of the vulva. Am Fam Physician 2008; 77: 321-6. American Family Physician
- Goldstein AT, Metz A. Vulvar lichen planus. Clin Obstet Gynecol 2005; 48: 818-23. PubMed
- Läkemedelsfrågan: Betablockerare kan ge lichen planus. Läkartidningen.se 2015-02-23. www.lakartidningen.se
- Powell J, Marren P, Wojnarowska F. Erosive vulvovaginitis. In: Black MM, ed. Obstetric and Gynecologic Dermatology. 2nd ed. London, UK: Mosby; 2002: 143-54.
- Pelisse M. The vulvo-vaginal-gingival syndrome. A new form of erosive lichen planus. Int J Dermatol 1989; 28: 381-4. PubMed
- Moyal-Barracco M, Edwards L. Diagnosis and therapy of anogenital lichen planus. Dermatol Ther 2004; 17: 38-46. PubMed
- Cooper SM, Wojnarowska F. Influence of treatment of erosive lichen planus of the vulva on its prognosis. Arch Dermatol 2006; 142: 289-94. PubMed
- Markusen TE, Barclay DL. Benign disorders of the vulva and vagina. In: DeCherney AH, Nathan L, eds. Current Obstetric and Gynecologic Diagnosis and Treatment. 9th ed. New York, NY: Lange Medical Books/McGraw-Hill; 2003: 651-76.
- Anderson M, Kutzner S, Kaufman RH. Treatment of vulvovaginal lichen planus with vaginal hydrocortisone suppositories. Obstet Gynecol. 2002; 100: 359-62. PubMed
- Assmann T, Becker-Wegerich P, Grewe M, Megahed M, Ruzicka T. Tacrolimus ointment for the treatment of vulvar lichen sclerosus. J Am Acad Dermatol 2003; 48: 935-7. PubMed
- Byrd JA, Davis MD, Rogers RS. Recalcitrant symptomatic vulvar lichen planus: response to topical tacrolimus. Arch Dermatol 2004; 140: 715-20. PubMed
- Lotery HE, Galask RP. Erosive lichen planus of the vulva and vagina. Obstet Gynecol 2003; 101: 1121-5. PubMed
- Jensen JT, Bird M, Leclair CM. Patient satisfaction after the treatment of vulvovaginal erosive lichen planus with topical clobetasol and tacrolimus: a survey study. Am J Obstet Gynecol 2004; 190: 1759-63. PubMed
- Goldstein AT, Parneix-Spake A, McCormick CL, Burrows LJ. Pimecrolimus cream 1% for treatment of vulvar lichen simplex chronicus: an open-label, preliminary trial. Gynecol Obstet Invest 2007; 64: 180-6. PubMed
- Dwyer CM, Kerr RE, Millan DW. Squamous carcinoma following lichen planus of the vulva. Clin Exp Dermatol 1995; 20: 171-2. PubMed
- Derrick EK, Ridley CM, Kobza-Black A, McKee PH, Neill SM. A clinical study of 23 cases of female anogenital carcinoma. Br J Dermatol 2000; 143: 1217-23. PubMed
- Franck JM, Young AW. Squamous cell carcinoma in situ arising within lichen planus of the vulva. Dermatol Surg 1995; 21: 890-4. PubMed
- Barbro Larson, docent och specialist i gynekologi och obstetrik, Stockholm
- Anna Nager, med dr och specialist i allmänmedicin, Karolinska institutet