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Infertilitet

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Sakkunnig:


Definition:
Avsaknad av befruktning efter ett år med oskyddade samlag.
Förekomst:
Infertilitet upplevs av 10–15 % av befolkningen i perioder eller permanent.
Symtom:
Vanligen inga symtom.
Kliniska fynd:
Vanligen normala kliniska fynd hos kvinnan och mannen.
Diagnostik:
Tilläggsundersökningar kan vara hormonprover, spermieundersökning och eventuellt bilddiagnostik.
Behandling:
Behandling riktas mot eventuella underliggande orsaker, eventuellt assisterad befruktning.
  1. Jose-Miller AB, Boyden JW. Infertility. Am Fam Physician 2007; 75: 849-56. PubMed  
  2. Taylor A. ABC of subfertility. Making a diagnosis. BMJ 2003; 327: 494-7. PubMed  
  3. Effective Health Care. The management of subfertility. Effective Health Care Bulletin 1992; 3: 13. PubMed  
  4. Duckitt K. Infertility and subfertility. Clin Evid 2004; 11: 2427-58. Clinical Evidence  
  5. Gnoth C, Godehardt D, Godehardt E, Frank-Herrmann P, Freundl G. Time to pregnancy: results of the German prospective study and impact on the management of infertility. Hum Reprod 2003; 18: 1959-66. PubMed  
  6. Van Voorhis BJ. In vitro fertilization. N Engl J Med 2007; 356: 379-86. PubMed  
  7. Hamilton-Fairley D, Taylor A. ABC of subfertility. Anovulation. BMJ 2003; 327: 546-9. PubMed  
  8. Pomp E. Ikke-steroide antiinflammatoriske legemidler og kvinnelig infertilitet. Tidsskr Nor Lægeforen 2002; 122: 2295-6. PubMed  
  9. Tersigni C, Castellani R, de Waure C et al. Celiac disease and reproductive disorders: meta-analysis of epidemiologic associations and potential pathogenic mechanisms.Hum Reprod Update. 2014 Jul-Aug;20(4):582-93. PMID: 24619876 PubMed  
  10. Huber-Buchholz MM, Carey DG and Norman RJ. Restoration of reproductive potential by lifestyle modification in obese polycystic ovary syndrome: role of insulin sensitivity and luteinizing hormone. J Clin Endocrinol Metab 1999; 84: 1470-4. PubMed  
  11. Norman RJ, Dewailly D, Legro RS, Hickey TE. Polycystic ovary syndrome. Lancet 2007; 370: 685-97. PMID: 17720020 PubMed  
  12. Veltman-Verhulst SM, Hughes E, Ayeleke RO, Cohlen BJ. Intra-uterine insemination for unexplained subfertility. Cochrane Database of Systematic Reviews 2016, Issue 2. Art. No.: CD001838. DOI: 10.1002/14651858.CD001838.pub5. DOI  
  13. Schmidt L, Munster K. Infetility, involuntary infecundity, and the seeking of medical advice in industrialized countries 1970-1992: a review of concepts, measurements and results. Hum Reprod 1995; 10: 1407-18. PubMed  
  14. Read J. Sexual problems associated with infertility, pregnancy, and ageing. BMJ 2004; 329: 559-61. PubMed  
  15. Kallen B, Finnstrøm O, Nygren KG et al. In vitro fertilisation in Sweden: obstetric characteristics, maternal morbidity and mortality. BJOG 2005; 112: 1529-35. pmid:16225574 PubMed  
  16. Collins JA, Burrows EA, Willan AR. The prognosis for live birth among untreated infertile couples. Fertil Steril 1995; 64: 22-8. PubMed  
  17. Templeton A, Morris JK. IVF - factors affecting outcome. In: Templeton A, Cooke ID, O'Brien PMS, eds. 35th RCOG study group evidence-based fertility treatment. London: RCOG Press, 1998.
  18. Spector LG, Brown MB, Wantman E et al. Association of In Vitro Fertilization With Childhood Cancer in the United States. AMA Pediatr. 2019 Apr 1:e190392. PMID: 30933244 PubMed  
  • Britt Friberg, docent och överläkare, Reproduktionsmedicinskt Centrum, Skånes universitetssjukhus/Malmö
  • Anna Nager, med dr och specialist i allmänmedicin, Karolinska institutet