Gå direkt till huvudinnehållet

Allergenspecifik immunterapi, ASIT

Senast uppdaterad: Senast reviderad:
Sakkunnig:


  1. Svenska Föreningen för Allergologi. Allergenspecifik immunterapi. Rekommendationer för läkare och sjuksköterskor. Revidering av tidigare rekommendationer från år 2009. Svenska Föreningen för Allergologi. 2009. www.sffa.nu  
  2. Allergen immunotherapy: therapeutic vaccines for allergic diseases. Geneva: January 27-29, 1997. Allergy 1998; 53(44 suppl): 1-42.
  3. Varney VA, Edwards J, Tabbah K, Brewster H, Mavroleon G, Frew AJ. Clinical efficacy of specific immunotherapy to cat dander: a double-blind, placebo-controlled trial. Clin Exp Allergy 1997; 27: 860-7. PubMed  
  4. Olsen OT, Larsen KR, Jacobsan L, Svendsen UG. A one-year, placebo-controlled, double-blind house-dust-mite immunotherapy study in asthmatic adults. Allergy 1997; 52: 853-9. PubMed  
  5. Golden DBK, Kagey-Sobotka A, Norman PS, Hamilton RG, Lichtenstein LM. Outcomes of allergy to insect stings in children, with and without venom immunotherapy. N Engl J Med 2004; 351: 668-74. New England Journal of Medicine  
  6. Lockey RF, Nicoara-Kasti GL, Theodoropoulos DS, Bukantz SC. Systemic reactions and fatalities associated with allergen immunotherapy. Ann Allergy Asthma Immunol 2001; 87(1 suppl 1): 47-55.
  7. Joint Task Force on Practice Parameters. Allergen immunotherapy: a practice parameter. Ann Allergy Asthma Immunol 2003; 90(1 suppl 1): 1-40.
  8. Akdis C, Blasser K, Akdis M. Genes of tolerance. Allergy 2004; 59: 897-913. PubMed  
  9. Durham SR, Walker SM, Varga EM, Jacobson MR, O'Brien F, Noble W, et al. Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med 1999; 341: 468-75. New England Journal of Medicine  
  10. Abramson MJ, Puy RM, Weiner JM. Allergen immunotherapy for asthma (Cochrane Review). In: The Cochrane Library, issue 1, 2004. The Cochrane Library  
  11. Ross RN, Nelson HS, Finegold I. Effectiveness of specific immunotherapy in the treatment of asthma: a meta-analysis of prospective, randomized, single or double-blind, placebo-controlled studies. Clin Ther 2000; 22: 329-41. PubMed  
  12. Abramson MJ, Puy RM, Weiner JM. Is allergen immunotherapy effective in asthma? A meta-analysis of randomized controlled trials. Am J Respir Crit Care Med 1995; 151: 969-74. PubMed  
  13. Varney VA, Gaga M, Frew AJ et al. Usefulness of immunotherapy in patients with severe summer hay fever uncontrolled by antiallergic drugs. BMJ 1991; 302: 265-9. British Medical Journal  
  14. Radulovic S, Calderon MA, Wilson D, Durham S. Sublingual immunotherapy for allergic rhinitis. Cochrane Database of Systematic Reviews 2010, Issue 12. Art. No.: CD002893. DOI: 10.1002/14651858.CD002893.pub2 DOI  
  15. Calderon MA, Penagos M, Sheikh A, et.al. Sublingual immunotherapy for treating allergic conjunctivitis. Cochrane Database of Systematic Reviews 2011, Issue 7. Art. No.: CD007685. DOI: 10.1002/14651858.CD007685.pub2. DOI  
  16. Di Bona D, Plaia A, Leto-Barone MS, et al. Efficacy of grass pollen allergen sublingual immunotherapy tablets for seasonal allergic rhinoconjunctivitis: A systematic review and meta-analysis. JAMA Intern Med. 2015. doi: 10.1001/jamainternmed.2015.2840 DOI  
  17. Moller C, Dreborg S, Ferdousi HA, Halken S, Host A, Jacobsen L, et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J Allergy Clin Immunol 2002; 109: 251-6. PubMed  
  18. Grembiale RD, Camporota L, Naty S, Tranfa CM, Djukanovic R, Marsico SA. Effects of specific immunotherapy in allergic rhinitic individuals with bronchial hyperresponsiveness. Am J Respir Crit Care Med 2000; 162: 2048-52. PubMed  
  19. Des Roches A, Paradis L, Menardo JL, Bouges S, Daures JP, Bousquet J. Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children. J Allergy Clin Immunol 1997; 99: 450-3. PubMed  
  20. Huggins JL, Looney RJ. Allergen immunotherapy. Am Fam Physician 2004; 70: 689-96. PubMed  
  21. Jacobsen L, Nüchel Petersen B, Wihl JA et al. Immunotherapy with partially purified and standardized tree pollen extracts. IV. Results from long-term (6-year) follow-up. Allergy 1997; 52: 914-20. PubMed  
  22. Frølund L, Durham SR, Calderon M, et al. Sustained effect of SQ-standardized grass allergy immunotherapy tablet on rhinoconjunctivitis quality of life. Allergy 2009; : PMID: 17033900. PubMed  
  23. Rak S, Yang WH, Pedersen MR, Durham SR. Once-daily sublingual allergen-specific immunotherapy improves quality of life in patients with grass pollen-induced allergic rhinoconjunctivitis: a double-blind, randomised study. Qual Life Res 2007; 16: 191-201. PubMed  
  24. Nelson HS. The use of standardized extracts in allergen immunotherapy. J Allergy Clin Immunol 2000; 106(1 pt 1): 41-5.
  25. Bufe A, Eberle P, Franke-Beckmann E, et al. Safety and efficacy in children of an SQ-standardized grass allergen tablet for sublingual immunotherapy. J Allergy Clin Immunol 2009; 123: 167-73. PubMed  
  26. Lee S, Nolte H, Benninger MS. Clinical considerations in the use of sublingual immunotherapy for allergic rhinitis. Am J Rhinol Allergy. 2015;29(2):106-14 PubMed  
  27. McHugh SM, Lavelle B, Kemeny DM, Patel S, Ewan PW. A placebo-controlled trial of immunotherapy with two extracts of Dermatophagoides pteronyssinus in allergic rhinitis, comparing clinical outcome with changes in antigen-specific IgE, IgG, and IgG subclasses. J Allergy Clin Immunol 1990; 86(4 pt 1): 521-31.
  28. Turkeltaub P. Deaths associated with allergenic extracts. FDA Medical Bulletin 24, May 1994.
  29. Pumphrey RS. Lessons for management of anaphylaxis from a study of fatal reactions. Clin Exp Allergy 2000; 30: 1144-50. PubMed  
  • Anna Nager, med dr och specialist i allmänmedicin, Karolinska institutet